In addition, it also found that 18F-APN-1607 uptake was closely related to the cognitive changes, and the regional uptakes of AD-related cortical areas were significantly correlated with Alzheimer’s Disease Assessment Scale-Cognitive section (ADAS-cog) score, indicating that tau deposition may be related to the clinical severity of AD (Hsu et al., 2020). Here, MAPT is linked to Alzheimer disease.