KEAP1 and post-traumatic stress disorder: And our previous work further found that early intervention or pretreatment with EA could enhance hippocampal neurogenesis and prevent PTSD-like behaviors in a rat model of PTSD through the Keap1/Nrf2 antioxidant signaling and endocannabinoid signaling (Xue et al., 2019; Zhou et al., 2019).