CNR1 and neoplasm: The anticancer potential of the remaining compounds requires further research, as is the case with, for example, cannabinoids; animal studies showed that the activation of cannabinoid receptors 1 and 2 by tetrahydrocannabinol (THC) results in impaired proliferation and invasion of cancer cells, induces apoptosis (accumulation of ceramides in culture), and further reduces the tumor volume (McAllister et al., 2005; Galanti et al., 2008; Marcu et al., 2010; Abrams, 2016).