Genes within this region, like TERC, PHC3, TNIK, MIR569, NLGN1, TBL1XR1, KCNMB3, ZNF639 and USP13 are responsible for cancer development or progression when overexpressed or duplicated (Baena-Del Valle et al., 2018[3]; Chaluvally-Raghavan et al., 2014[11]; Crea et al., 2013[14]; Davidson et al., 2014[15]; Han et al., 2016[29]; Kang et al., 2009[38]; Lee et al., 2019[43]; Lin et al., 2005[49]; Xi et al., 2019[75]). The gene discussed is PHC3; the disease is cancer.