Patient P2 with AML and 50 % bone marrow cells with abnormal karyotype displayed 29 % RAD9A mean methylation whereas patient P3 with PBL and 60 % cells of his bone marrow cells showed complex aberrations had a RAD9A mean methylation of 41 % (Figure 2A(Fig. 2)). The gene discussed is RAD9A; the disease is acute myeloid leukemia.