Although this finding may not explain the down-regulation of RAD9A in our 2N collective, considering our experiments done in this study we propose that mosaic RAD9A hypermethylation is an early (either stochastic or environmentally induced) event, which may increase the probability of malignant transformation in regular body cells (predisposing factor) or/and a factor that signals the tumor progression itself (oncogenic factor) for this mainly 1N patients. Here, RAD9A is linked to neoplasm.