A few studies suggested that elevated SOX9 expression was associated with either tumor aggressiveness or worse patient survival: One small scale study based on gastric cancer biopsies demonstrated high SOX9 expression was associated with more advanced tumor TNM stage and lower overall survival and disease-free survival (19); Another study only found correlation of SOX9 expression with TNM and clinical stages (23); Two other cohort studies did not find any significant relationship between altered expression of SOX9 protein and clinicopathological parameters including overall survival (24,25). This evidence concerns the gene SOX9 and neoplasm.