IRS1 and Obesity: Thus, the presence of the C allele of the IRS1 gene (rs2943640) may indicate risk of high insulin resistance in type 2 diabetic patients regardless of the presence/absence of comorbid obesity and chronic pancreatitis; in type 2 diabetic patients (carriers of C allele of the IRS1 gene (rs2943640)) with comorbid obesity and chronic pancreatitis, actually, chronic pancreatitis is more important factor in insulin resistance progression.