Five genes at 6q27 exhibiting large genomic changes (PSMB1, PDCD2, TBP, OR4F7P and WBP1LP8) were found in HCI-010 as the region transitioned from amplified in the human tumor to deleted in the early passage of the PDX and PDxO (Extended Data Fig. 5). The gene discussed is PSMB1; the disease is neoplasm.