In other words, a given BRCA1 mutation known to disrupt the activity of the wild-type allele will always be declared as functionally relevant (i.e., loss of function) regardless of tumor-context considerations such as the germline versus somatic origin of the variant, the status of the second allele and/or the cancer type in which it is observed, which are contemplated in the actionability analysis (next section). This evidence concerns the gene BRCA1 and cancer.