BRCA1 and ovarian cancer: Note that different types of assertions can be equally mapped to the context-agnostic notion of a variant being functionally relevant; for example, a given BRCA1 mutation can be considered as a putative loss-of-function event when it is known to predispose to early breast/ovarian cancer, as well as when it is associated with clinical efficacy of poly-ADP ribose polymerase inhibitors.