TFRC and colorectal carcinoma: In addition, ferroptosis is characterized by iron accumulation and lipid ROS induction.12 Accordingly, NFS1 knockdown robustly increased the transferrin receptor 1 (TFRC) level and reduced the translation of ferritin heavy chain (FTH1) level which function as iron-responsive proteins to induce iron accumulation in CRC cells lacking NFS1 (Fig. 2g, i).