NFS1 plays a pivotal role in Fe–S cluster assembly and several Fe–S cluster-dependent pathways to impact tumor development.12,34 The depletion of NFS1 combined with the inhibition of cysteine transport results in insufficient Fe–S cluster maintenance, activation of the iron-starvation response and subsequent triggering of ferroptosis.12 NFS1 inhibition induces persistent DNA damage and leads to cell death in breast cancer.34 However, the influence and regulation of NFS1 in CRC remain elusive. The gene discussed is NFS1; the disease is breast carcinoma.