Because cancer cells can modify a set of defense mechanisms, including the assembly of Fe–S clusters, to survive during redox stress16 and that platinum-based chemotherapy treatment could increase ROS level (Fig. 4b, f), we subsequently explored the regulatory effect of oxaliplatin on NFS1 and found that the mRNA and protein levels of NFS1 were unaffected by oxaliplatin treatment based on the sensitivity to oxaliplatin (Supplementary Fig. S5a, b and Fig. 5a). Here, NFS1 is linked to cancer.