Data from the TCGA database indicated that NFS1 is overexpressed in multiple human tumors including colon adenocarcinoma (COAD) (Supplementary Fig. S6a), and finding from our hospital cohort showed that NFS1 mRNA was more highly expressed in CRC and esophageal squamous cell carcinoma (ESCC) tumor tissues than in matched normal tissues (Fig. 7a and Supplementary Fig. S6b). Here, NFS1 is linked to neoplasm.