As NFS1 and FDX2 are two essential metabolic enzymes in Fe–S cluster biosynthesis whereby NFS1 harvests sulfur from cysteine residues and FDX2 transfers electrons for the initial step19 (Fig. 1d), which suggests that NFS1 and FDX2 could induce oxaliplatin resistance in CRC. Here, FDX2 is linked to colorectal carcinoma.