This fact is consistent with the recently proposed concept of “PANoptosis”.3 Interferon regulatory factor 1 (IRF1), TNF-α, and IFN-γ have been shown to induce PANoptosis to prevent tumorigenesis, particularly in CRC colitis-associated tumorigenesis.4,5 However, the role of PANoptosis in tumor chemosensitivity has not been elucidated. Here, IRF1 is linked to colorectal carcinoma.