All in all, the results indicate circEHD2 sponges miR-3186-3p to mediate FOXK1, thereby motivating NSCLC proliferation and glycolysis, but repressing autophagy and apoptosis, clarifying that circEHD2 is able to be a latent therapeutic target for NSCLC. This evidence concerns the gene FOXK1 and non-small cell lung carcinoma.