CD274 and gastric cancer: The Cancer Genome Atlas (TCGA) project proposed a molecular classification based on comprehensive genomic modeling, dividing GC into 4 subtypes: Epstein-Barr virus (EBV)–positive tumors, microsatellite instability-high (MSI-H) tumors, genomically stable tumors, and tumors with chromosomal instability.4 Among them, the correlation between high expression of programmed death ligand-1 (PD-L1) and prognosis in patients with GC has been extensively investigated.