However, a recent study by Kawazoe and colleagues33 reported an association between PD-L1 expression and clinicopathological parameters (TCs: mismatch repair deficient, PIK3CA mutation, and KRAS mutation; immune cells: EBV positivity and lymph node metastasis) using the IHC 22C3 pharmDx kit in metastatic GC, but IC and TC were scored separately in the study. The gene discussed is PIK3CA; the disease is metastatic malignant neoplasm in the lymph nodes.