ACE2 and COVID-19: Interestingly, childrenseem less affected than adults and when infected, present with differentsymptomatology, that is, more gastro-intestinal symptoms and less pulmonarycomplaints.1,2Reasons for this are largely unknown, but might be attributable to differentexpression of angiotensin-converting enzyme 2 (ACE2) between children and adults.ACE2 is a metallopeptidase also functioning as receptor for SARS-CoV andSARS-CoV-2,3,4responsible for COVID-19.