We found that maternal diabetes induction (STZ‐HSCT/STZ/EMP) significantly decreased SYP levels in the hypothalamus but had no effect on SOD2 and ERβ, compared with the control (CTL‐HSCT/CTL/EMP) group; the STZ‐HSCT/STZ/↑Sod2 and CTL‐HSCT/CTL/shSod2 groups showed no effect (Fig. S5A, online only). This evidence concerns the gene ESR2 and diabetes mellitus.