KRAS and non-small cell lung carcinoma: Next, in addition to what is shown for NSCLC A549 cells in Fig. 2G and for SK-LU1 cells in Fig. 2H, additional KRAS-mutated NSCLC cell lines, namely HTB56 (Fig. 5C) and A427 (Fig. 5D), with the mutation patterns defined in the Fig. 5 and accomplished KRAS-siRNA-knockdown (Fig. 5B), also showed significantly decreased colony growth (Fig. 5C, D) when treated with appropriate KRAS-siRNA nanocarriers as compared to cells treated with control-siRNA carriers or untreated cells (phosphate buffered saline (PBS)).