CCA subtypes differ not only in their location but also in their etiopathogenesis and molecular aberrations, along with the emerging evidence pointing towards a different proposed cell of origin,31 as iCCA is mostly derived from trans-differentiation of adult hepatocytes or their progenitor cells, whereas eCCA is derived from ductal cells, suggesting that eCCA and iCCA are distinct molecular entities. Here, PRRT2 is linked to cholangiocarcinoma.