ERBB2 and neoplasm: Next, we investigated the intercellular communication landscapes between T cells and epithelial cells in either normal tissue or tumor tissue using iTALK,29 which indicated that ERBB2 receptor was enhanced in tumor tissues during intercellular communications between T cell and epithelial cells, suggesting that blocking the ERBB2 signaling may affect the proliferation effects in malignant cells (Figure 6, E).