All of those TFs have been shown to play vital roles in the tumorigenesis and tumor progression processes.23, 24, 25, 26, 27 Interestingly, the top 2 DEG of M1- GEB7, was a strong target of SMARCC2; one of the targets of EGR1 was MUC6, which was the most highly expressed gene in M2; FYN, which was the top 1 DEG of M3, was among the targets of all representative TFs of M3 - IKZF1, RUNX3, CREM, and STAT4. The gene discussed is CREM; the disease is neoplasm.