HSF1 and neurodegenerative disease: Celastrol, arimoclomol, and BGP-15 did not show any effect on HSF1 activation and endogenous target gene expression in our system although there are promising results from cell culture and animal models and even clinical trials for various diseases caused by dysregulated protein homeostasis (e.g., neurodegenerative diseases, lysosomal dysfunctions, and muscular dystrophy) [72–77].