Relative to sham group, TAC for 4 weeks in WT mice markedly accelerated myocardial hypertrophy, as shown by higher ratios of heart weight/body weight (HW/BW) and heart weight/tibia length (HW/TL), left ventricular (LV) wall thickness, cardiac myocyte size, and the mRNA levels of ANF and BNP. Here, NPPB is linked to cardiac hypertrophy.