PNPLA2 and cardiac hypertrophy: After 4 weeks of TAC surgery, TAC-induced suppression of cardiac functions (decreased FS%) (Fig. 7a), and enhancement of cardiac hypertrophy (increased LV wall thickness, ratios of HW/TL, and myocyte area) (Fig. 7b–c), fibrosis (Fig. 7d), superoxide production (Fig. 7e), and myocyte apoptosis (Fig. 7f) in vehicle-treated WT hearts were further aggravated in VO-OHpic-administered ATGL KO mice (Fig. 7a–f).