For other four lncRNAs (ENSG00000204949.7, ENSG00000273038.2, ENSG00000269609.4 and ENSG00000273230.1) failed in the independent validation, FAM83A-AS1 (ENSG00000204949.7) and RP11-479G22.8 (ENSG00000273038.2) play essential roles in the development and progression of several cancers, including lung cancer, esophageal cancer and hepatocellular carcinoma (Wei and Zhang 2016; Wu et al. 2018; He and Yu 2019; Shi et al. 2019; Huang et al. 2020; Jia et al. 2021). The gene discussed is SACK1A; the disease is hepatocellular carcinoma.