SHBG and myocardial infarction: The improved lipid profile (increased levels of high-density lipoprotein cholesterol and lower levels of triglycerides) mediated most of the protective effects of higher genetically predicted SHBG levels on coronary atherosclerotic outcomes from 78% (95% CI: 30%, 100%) for myocardial infarction to 96% (95% CI: 25%, 100%) for angina pectoris (Supplementary Table S12, available as Supplementary data at IJE online).