Importantly, BCR diversity was lower (i.e. increased clonality) and SHM was higher in primary tumour and regional subcutaneous metastases compared with distant metastases (Selitsky et al., 2019) and decreased BCR diversity was associated with better survival in melanoma (Bolotin et al., 2017; Iglesia et al., 2016; Selitsky et al., 2019). This evidence concerns the gene BCR and neoplasm.