Syndromes with the highest number of associated genes are Kallmann (ANOS1, CHD7, DUSP6, FEZF1, FGF17, FGF8, FGFR1, FLRT3, FSHB, GNRH1, GNRHR, HS6ST1, IL17RD, KISS1, KISS1R, LHB, NDNF, NSMF, PROK2, PROKR2, SEMA3A, SPRY4, TAC3, TACR3, WDR11) and Noonan syndrome (PTPN11, KRAS, SOS1, RAF1, NRAS, BRAF, LZTR1, SOS2, and RIT1). Here, SOS2 is linked to Noonan syndrome.