Syndromes with the highest number of associated genes are Kallmann (ANOS1, CHD7, DUSP6, FEZF1, FGF17, FGF8, FGFR1, FLRT3, FSHB, GNRH1, GNRHR, HS6ST1, IL17RD, KISS1, KISS1R, LHB, NDNF, NSMF, PROK2, PROKR2, SEMA3A, SPRY4, TAC3, TACR3, WDR11) and Noonan syndrome (PTPN11, KRAS, SOS1, RAF1, NRAS, BRAF, LZTR1, SOS2, and RIT1). This evidence concerns the gene SOS1 and Noonan syndrome.