Yamashita et al.19investigated the clinical utility of the aMAP score for predicting HCC occurrence and the incidence‐free rate after a sustained virologic response in chronic hepatitis C. The current study was a retrospective, longitudinal study applying the AFP, Doylestown algorithm, and aMAP score to consecutive time points for patients with liver cirrhosis to compare the performance of the algorithm in detecting HCC. This evidence concerns the gene AFP and cirrhosis of liver.