The increased size of the somas of intrinsic neurons (NeuN-positive and TH-positive) related to ovarian cysts and OS in senescent animals, coupled with a significant decrease in the number of these neurons, allows us to propose an exacerbated cell machine in the maintenance of ovarian cysts and high concentration of NE related to reproductive senescence and various pathologies (Chavez-Genaro et al. 2007; Cruz et al. 2017). Here, RBFOX3 is linked to Ovarian cyst.