Country differences remained relatively stable across age groups, with no strong indication that the U.S. disadvantage is larger in the middle-aged cohorts subject to recent attention in mortality analyses, except only for self-reported hypertension and high level of CRP, for which the U.S. disadvantage was larger among those aged 50–64 and 65–74; also the prevalence of Class I and II obesity was higher in the United States compared to England particularly among these age groups. The gene discussed is CRP; the disease is obesity disorder.