Through a literature review, we found that RCC2 has been reported to be an oncogene and that overexpression of RCC2 induced epithelial-mesenchymal transition to promote the proliferation, invasion, and migration of lung adenocarcinoma cells; RCC2 can also be driven by BRD4 to promote the growth of esophageal squamous cell carcinoma, although this has not been reported in leukemia35–38. This evidence concerns the gene RCC2 and esophageal squamous cell carcinoma.