Previous studies have suggested that knockdown of METTL14, FTO, ALKBH5, or YTHDF2 has a stronger inhibitory effect on leukemogenesis than on normal hematopoiesis and that m6A RNA methylation is important in the occurrence and progression of AML, suggesting that m6A regulators may serve as potential therapeutic targets for the eradication of leukemia cells. The gene discussed is YTHDF2; the disease is leukemia.