GSDMD and triple-A syndrome: The main findings of this study are: (1) cell pyroptosis and NLRP3 inflammasome were involved in AAA formation; (2) activating α7nAChR alleviated AAA injury and restrained inflammation; (3) α7nAChR deficiency promoted AAA formation; (4) protective effects of activating α7nAChR against cell pyroptosis in AAA were dependent on NLRP3/GSDMD pathway.