CEACAM5 and non-small cell lung carcinoma: As shown in Fig. 4a, the screening efficacy of CTSF (AUC = 0.813 cut-off value:76.25 sensitivity:95.6% specificity:53.5%) or FBLN1 (AUC = 0.899 cut-off value:111.04 sensitivity:83.6% specificity:80.7%) was better than that of CEA, CA125, SCC, and CYFRA211 as these classical markers could not distinguish BM from NSCLC (P > 0.05).