AKR1B10 and non-small cell lung carcinoma: Serum levels of CTSF and FBLN1 were significantly elevated in LCBM compared to controls (P < 0.001 for both) (Fig. 2E, F) while AKR1B10 was elevated in all groups with advanced NSCLC (LCBM, LM, BoM and ALC) irrespective of BM (Fig. 2G).