Among these proteins, we focused on 10 proteins (CTSF, FBLN1, AKR1B10, CCL20, SAA1, CXCL1, CXCL3, AXL, AKR1C3, CPNE 3) based on the extent of upregulation and their close relationship with the occurrence and development of tumours reported in previous studies (Fig. 2c). The gene discussed is AKR1C3; the disease is neoplasm.