We examined the expressions of CTSF, FBLN1 and AKR1B10 in BM tissues of 47 patients with NSCLC BM using IHC (cohort 3); 10 of these patients underwent orthotopic tumour excision in the early stages of the disease and the corresponding primary tumour tissues were also obtained. The gene discussed is AKR1B10; the disease is neoplasm.