ESR1 and neoplasm: Of note, the induction of Sam68 silencing was able to delay the growth of tumor xenografts generated by the injection of BRCA wt TNBC cell lines, whereas those obtained by ER+ were not significantly influenced, likely due to the different role of Sam68 in tumor development according to the divergent TP53 mutational status of these cell lines (Fig. 2G and Supplementary Fig. S2N) [32, 33].