We tested the effect on the expression of 3 representative NKG2DL, i.e. MICA, MICB and ULBP1, in 3 acute myeloid leukemia (AML) cell lines with different p53 status: OCI-AML3 cells express wild type p53 (wt p53), HL60 are p53 null and NB4 express mutant p53 (mut p53) and in a primary cell line that we derived from a B-cell lymphoma patient (BCL-P2) with wt p5315,16. The gene discussed is ULBP1; the disease is acute myeloid leukemia.