In our initial analysis of 11 T-ALL cell lines, we identified highly active tyrosine kinases (LCK, SRC, FYN, YES1, LYN, INSR, and IGF-1R) as well as serine/threonine kinases (CDK1/2, AKT, and PAK1/2). Here, PAK1 is linked to acute lymphoblastic leukemia.