In our initial analysis of 11 T-ALL cell lines, we identified highly active tyrosine kinases (LCK, SRC, FYN, YES1, LYN, INSR, and IGF-1R) as well as serine/threonine kinases (CDK1/2, AKT, and PAK1/2). The gene discussed is YES1; the disease is acute lymphoblastic leukemia.