Interestingly, the ETP-ALL-like cell line LOUCY and the LMO2-rearranged MOLT-16 cells show activation of LYN and HCK as well (Fig. 1b, e), indicating that subsets of T-ALL cells can present myeloid-like signaling features, along with the expression of known immature markers such as CD34. Here, HCK is linked to acute lymphoblastic leukemia.