Interestingly, Gocho and colleagues showed modulation of INSR activity upon dasatinib treatment in dasatinib-sensitive T-ALL patient-derived murine xenografts35, further strengthening the observation that the INSR/IGF-1R and SFKs signaling can be interconnected and can mutually affect each other, as summarized in Fig. 5c, and illustrated in kinase-substrate relation networks in Supplementary Fig. 8. The gene discussed is INSR; the disease is acute lymphoblastic leukemia.