RHBDF2 and obesity due to melanocortin 4 receptor deficiency: Rhomboid 5 homolog 2 (Rhbdf2), also known as iRhom2, is an inactive member of the rhomboid intramembrane proteinase family that has been determined to be a pivotal pathogenic regulator of inflammation-related diseases, e.g., obesity, arthritis, nephritis, atherosclerosis, and fibrosis12–15.