Interestingly, in agreement with our data that include mGluR2/3 and EAAT2 in a cluster discriminating schizophrenia and control subjects, previous studies identified reduced EAAT2 expression in the PFC of subjects with high-risk GRM3 haplotype associated with schizophrenia63, and highlighted multiple EAAT2 interactome-associated biological pathways alteration in the disorder64. This evidence concerns the gene GRM2 and schizophrenia.