CLOCK and intervertebral disk degenerative disorder: Melatonin has been widely used for the treatment of many degenerative diseases, and multiple biological effects of melatonin, such as maintaining the central clock and antioxidation, antiaging, antiapoptotic, and anti-inflammatory effects, have been confirmed.52–55 Zheng et al. reported that melatonin could alleviate IDD by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop52.