ESR1 and breast cancer: The expression of ESR1 in ER positive breast cancer cells was reported to be associated with a distal super enhancer7, which localised in the same topologically associating domain (TAD) with ESR1 gene (Supplementary Fig. 5a) and characterised by high H3K27Ac, high H3K4me1, low H3K27me3 and DNase hypersensitivity (Supplementary Fig. 5b).