In particular, the results of H&E staining and IHC of tumors, and IHC of metastatic hepatic nodules from nude mouse xenograft tumor model reinforced that CCDC12 could accelerate nuclear division of cells, weaken intercellular adhesion and increase distance, and also downregulate the expression of E-cadherin, a typical epithelial state marker, and upregulate Vimentin, Fibronectin, Snail, Slug, MMP 2, and MMP 9, classical markers of mesenchymal state [17, 18]. Here, FN1 is linked to neoplasm.