CCDC12 and cancer: Through iTRAQ assays, we observed that overexpression of CCDC12 could induce expression levels changes in 169 proteins, which clarifies, on a smaller scale, the molecules that interact with CCDC12. In COG analysis, about one thousand proteins are annotated with definite functions and enriched in the following annotations: translation, ribosomal structure, and biogenesis [25]; transcription [26]; and signal transduction mechanisms [27], all of which have been strongly associated with cancer.