CCDC12 and colonic neoplasm: What is interesting is that CCDC12 overexpressed caused cells in the liver of mice to become tightly connected, which also echoed the performance after the knockdown of CCDC12. These findings demonstrate that over-expression of CCDC12 increases colon cancer cell proliferation, migration, and invasiveness both in vivo and in vitro while reducing apoptosis levels and promoting the development of cells towards the mesenchymal state.