Based on expression levels of CCDC12 in colon cancer cell lines (Fig. S1), HCT116 cell line and CCDC12-knocked SW480 cell line were selected to overexpress CCDC12 (OE-CCDC12 group, Figs. S5 and S3B), with NC group and Vec group as a knockdown. Here, CCDC12 is linked to malignant colon neoplasm.