AD + P participants showed increases in tau SUVR uptake especially localized in parietal (inferior and superior parietal, precuneus and supramarginal) and temporal regions, both lateral (middle and inferior temporal) and medial temporal (fusiform gyrus, parahippocampal gyrus and entorhinal cortex); AD + P patients also showed high tau binding in medial and lateral orbital frontal regions. The gene discussed is MAPT; the disease is Alzheimer disease.