PNPO and epilepsy: Here, we generated four Drosophila knock-in (KI) strains carrying either wild-type (WT) human pyridox(am)ine 5′-phosphate oxidase (hPNPO) allele (hWT) or one of three hPNPO epilepsy-associated alleles hR116Q, hD33V , and hR95H.