Interestingly, several proteins associated with cancer stem cells, including in glioma [CD166 (15), F2R/PAR1 (16), EDNRB (17), CX3CL1 (18), ITGA6 (19), and ITGA7 (20)] displayed induced surfaceome or endocytome expression in 3D vs. 2D cultures. Here, F2R is linked to central nervous system cancer.