Furthermore, the possible contribution of anti-LAG-3 to the durability of combination therapy response is supported by seven patients who received ieramilimab plus spartalizumab for over 3 years, including two of the patients achieving CR, one patient with a CR by irRC, plus four additional patients with mesothelioma, nasopharyngeal cancer, gastric cancer, and a malignant neoplasm of unknown primary who achieved PR. This evidence concerns the gene LAG3 and cancer.