There was no increase in incidence of immune-mediated SAEs, consistent with the observation that LAG-3 deficiency alone does not result in autoimmunity in preclinical models.26 In contrast to combination checkpoint blockade with anti-CTLA-4 and anti-PD-1 agents, the immune-mediated toxicity of ieramilimab in combination with spartalizumab was comparable to that seen with spartalizumab alone.14 No new safety signals were identified compared with existing immune checkpoint inhibitor treatments. This evidence concerns the gene CTLA4 and Autoimmunity.