APOE and early-onset autosomal dominant Alzheimer disease: Neuroimaging PheWAS was recently introduced as a web-based system to analyze gene-brain relationships, and could be used to study the influences of the apolipoprotein E (APOE) gene on various brain morphologic properties in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort; benchmark tests on the UK Biobank were performed as well (Zhao et al., 2021).