IFNA2 and endothelial dysfunction: Plasma levels of IFNA2 showed significant positive correlations with the markers of oxidative stress glutathione disulfide and 5-oxoproline, a byproduct of the γ-glutamyl cycle (Fig. 6A, compare IFNA2 to IFNW1 in SI Appendix, Fig. S10C), and negatively associated with markers of endothelial dysfunction and nitric oxide signaling (arginine, citrulline) (Fig. 6A; compare IFNA2 to IFNW1 in SI Appendix, Fig. S10D).