IFNB1 and COVID-19: This analysis revealed that a subset of IFNs is strongly anticorrelated with seroconversion (e.g., compare IFNA2 to IFNB1 in Fig. 4H) and specific Ig variable domains that have been previously found enriched in the bloodstream of COVID-19 patients, such as IGHV1-24 and IGLV3-1 (29).