CHMP2B and frontotemporal dementia: A FTD mouse model based on the CHMP2B mutation – a mutation that causes both ALS and FTD – has linked FTD-related social behaviours to alterations of Ca2+-impermeable AMPA receptors (ligand: glutamate) at excitatory synapses of pyramidal neurons in the prefrontal cortex (Gascon et al., 2014).