S100A8 and Sepsis: In terms of monocytes, upregulation of cMono and specifically higher abundance of CD14+CD33+HLADR− cells and S100A8/9/12 expressing cMono in severe/critical COVID-19 and sepsis is consistent with similar changes in monocytic myeloid-derived suppressor cells in both diseases, while similar reductions in ncMono and DCs were seen in both COVID-19 and sepsis.