Redox state (reflected by MTORC1 signaling and oxidative phosphorylation) was enriched across mononuclear phagocytes (MNP), T cells, NK cells, and plasmablasts in more severe COVID-19, as were cell cycle (MYC targets, E2F targets, G2M checkpoint) pathways (except for MNP), while IL2-STAT5 pathway enrichment in T cells was found in more severe disease. This evidence concerns the gene IL2 and COVID-19.