APCS and COVID-19: A multi-omic set of 81 features was discovered using SIMON (Tomic et al., 2021) (STAR Methods) (AUC = 0.85, 95% CI = 0.59–1), identifying specific differentially abundant genes, proteins (including FCN1 and APCS as higher in COVID-19) and significant pathway enrichment for hematopoietic cell lineage and the renin-angiotensin system (Figures S9D and S9E).