We found an innate response component specific to critical COVID-19 (component 247) with differential expression of granulocyte activation marker (CEACAM8), neutrophil elastase (ELANE) and defensins (DEFA1B/4), and increased soluble CD163 scavenger protein levels, reflected in pathway enrichment for neutrophil functions (Figure 7F). Here, CEACAM8 is linked to COVID-19.