CD8A and lymphopenia: The three modules most significantly correlated with severity (p < 1×10−10) were enriched for, respectively, cellular and functional neutrophil gene signatures and neutrophil count (MEblue module); CD8+ T cell signatures and relative lymphopenia (MEturquoise module); and granulocyte and common myeloid progenitor cell gene signatures, neutrophil degranulation, antimicrobial peptides, and defensin pathways (MEGrey60 module) (Figures S3F and S3G).