CLU and asthma: Contributing features to component 171 included raised plasma chemokines involved in chemotaxis and activation (CXCL8, CXCL10, and CCL20) and GM-CSF together with acute phase activating proteins (SAA1/2 and SERPINA3), LRG1, and LBP; reduced abundance of intermediate monocytes; high expression of cell stress chaperone CLU and methyltransferase METTL7B, and downregulation of IgE receptor and multiple HLA class II genes; and pathway enrichment for antigen presentation, TCR signaling, and asthma (Figure 7E).