JCHAIN and COVID-19: We additionally identified COVID-19 and influenza-associated components (Figures 7H and 7I) including widespread upregulation of immunoglobulin heavy/kappa/lambda genes, JCHAIN (regulating multimerization and mucosal secretion of IgM/IgA), and MZB1 (involved in antibody secretion and integrin-mediated cell adhesion) linking with possible antibody-dependent cellular toxicity (component 6); and significant upregulation of interferon pathway genes (component 235).