We found that autoreactive IGHV4-34 BCRs, which are elevated in autoimmunity (Pascual et al., 1991), were significantly depleted in IGHD/M but elevated in class-switched B cells, most notably for the IGHA2 and IGHG2 B cells (Figure 5E) consistent with class-switching of these autoreactive B cells during the response to SARS-CoV-2. Here, IGHA2 is linked to Autoimmunity.