As for p53 wild-type GBM cells, we used pifithrin-α (p53 inhibitor) to perform the rescue experiment, but the results indicated that pifithrin-α (PFT-a) could not significantly affect the impact of p62 overexpression on SLC7A11 (Fig. 5E) in A172 (p53 wild-type) cells. This evidence concerns the gene SQSTM1 and glioblastoma.