Ring finger protein 31 (RNF31, also named HOIP), Ran Bp-type and C3HC4-type zinc finger-containing protein 1 (RBCK1), and Ariadne homolog 1 (ARIH1) are members of RBR E3 ligases that are up-regulated in breast cancer [18, 196, 197]. The gene discussed is RNF31; the disease is breast cancer.