AKT1 and breast cancer: Therefore, there are many crosstalk between phosphorylation and other PTMs in breast cancer, for example, the crosstalk between methylation and phosphorylation; methylated ERα at R260 by PRMT1 triggers the PI3K-Akt signaling pathway to stimulate the downstream target proteins to undergo phosphorylation modification and resulting in breast cancer cell proliferation and antiapoptotic effects (Fig. 5D) [171].