PRMT7 and breast carcinoma: Intriguingly, some PRMTs undergo automethylation spontaneously, the automethylation of PRMT7 at R531 in the C-terminal of the protein accelerates the interaction with the transcription factor Yin-Yang 1 (YY1) and is vital for its recruitment to the promoter region of E-cadherin to inhibit transcription, thus promoting EMT and breast cancer cell migration and invasion (Fig. 5F) [19].