To date three serum glycoproteins including cancer antigen (CA 15–3) and CA 27–29 that encoded by MUC1 gene, and carcinoembryonic antigen (CEA) are regarded as traditional biomarkers used for clinically detection and monitor breast cancer occurrence and recurrence through serum glycoprotein immunoassays [49, 81, 128]. Here, CEACAM5 is linked to breast carcinoma.