Sirtuin 2 (SIRT2) is induced via the NOTCH signaling pathway to deacetylate aldehyde dehydrogenase A1 (ALDH1A1) at K353 leading to the increase of its enzyme activity and the promotion of breast cancer stem cells (CSCs) properties (Fig. 2F) [66]. This evidence concerns the gene ALDH1A1 and breast carcinoma.