PRMT1 catalyzes ERα methylation at R260 within the DNA binding domain during rapid estrogen signaling, leading to the activation of the downstream PI3K-Src-Akt signaling pathway, thus promoting the phosphorylation of Akt at Ser473 and resulting in cancer cell proliferation and antiapoptotic effects (Fig. 5D) [171]. This evidence concerns the gene AKT1 and cancer.