Acetylation of RelA/p65, a subunit of nuclear factor-kappa B (NF-κB), by p300 at K218, K221, and K310 activates NF-κB signal pathway and promotes the transcription of interleukin-8 (IL-8) to facilitate angiogenesis and tumor metastasis [61]. The gene discussed is NFKB1; the disease is neoplasm.