Moreover, many protein post-translational modifications are involved in the progression of breast cancer by regulating the activity of signaling pathways [61, 66, 67, 98, 106, 149, 171], the activation of most signaling pathways such as NF-κB, TGF-β-Smad4 and PI3K-Akt is a cascade of phosphorylation modification [61, 98, 106, 149]. The gene discussed is SMAD4; the disease is breast cancer.