Since in our experiments TFF3 knock-down did not influence MDA-MB-231 vascular mimicry ability, contrarily to other reports describing TFF3 as a promoter of tumor angiogenesis in breast cancer cells [45], the exposure to recombinant TFF3 did not restore the migratory ability in TFF3-silenced MDA-MB-231 cells, possibly due to a major role for intracellular rather than extracellular TFF3. Here, TFF3 is linked to breast carcinoma.