In in vivo functional assays, the tumor growth rate was comparable between the two experimental groups (Fig. 4G), as previously observed in vitro, while both sCTC and cCTC frequencies underwent about 50% decrease in the TFF3 knock-down versus control group (6/11 versus 10/11 sCTC+ve, and 5/11 versus 10/11 cCTC+ve, respectively). This evidence concerns the gene TFF3 and neoplasm.