PDCD2L and pachyonychia congenita: In order to verify the expression of PDCD2L in single cell in different cancers and its relationship with tumor functional status, we found that PDCD2L expression in prostatic cancer (PC) was significantly positively associated with apoptosis, PDCD2L expression in renal cell carcinoma (RCC) was significantly positively associated with cycle, and PDCD2L expression in Acute myeloid leukemia(AML) was significantly positively associated with invasion through CANCERSEA website (Fig. 5A).