To evaluate the role of antiapoptotic BCL-2 proteins on preclinical CRC models, Scherr et al. have found that BCL-XL is overactivated in CRC, which provides a promising therapeutic target for CRC by analyzing a pan-cancer cohort, [26].High ANKRD6 expression is correlated with poor prognosis of colon cancer based on a pan-cancer analysis, which suggests ANKRD6 plays an important role in the progression of colon cancer [27]. This evidence concerns the gene BCL2 and colonic neoplasm.