The other frequently recurrent PVs c.211dupA [24, 25, 27, 28, 31] and c.5266dupC [24–28, 30] were found in 55.6% (30/54) of BRCA1-related hereditary breast and ovarian cancer (HBOC) in Tunisian families but neither in Algerian nor in Moroccan families with BC and/or OC. Here, BRCA1 is linked to breast cancer.