GH1 and metabolic dysfunction-associated steatotic liver disease: On the one hand, prior studies have suggested that there was a potential interaction between GH deficiency and NAFLD in adolescents and adults [4–6], and replacement therapy with recombinant human GH (rhGH) has demonstrated favorable effects in GH deficiency patients due to the fact that it often significantly improves the hepatic steatosis and fibrosis [4–8].