INS and cancer: Also, we analyzed the down-regulated DGEs of 411 overlapping genes, and found that the down-regulated DGEs in “HN vs. NN” were mainly concentrated in AMPK signaling pathway, Insulin resistance, MAPK signaling pathway, Pathways in cancer, Fatty acid degradation, Glucagon signaling pathway and Thermogenesis; The down-regulated DGEs in “HB vs. NN” were mainly concentrated in the AMPK signaling pathway, Pathways in cancer, Fatty acid degradation, Insulin resistance, Glucagon signaling pathway and Thermogenesis (Additional files 4 and 5).