INS and early-onset autosomal dominant Alzheimer disease: We analyzed the up-regulated DGEs of 411 overlapping genes, and found that the up-regulated DGEs in “HN vs. NN” were mainly concentrated in Pathways in cancer, HIF-1 signaling pathway, Insulin signaling pathway, Foxo signaling pathway and Alzheimer’s disease; The up-regulated DGEs in “HB vs. NN” were mainly concentrated in the Pathways in cancer, HIF-1 signaling pathway, Alzheimer disease, Insulin signaling pathway, and PI3K-Akt signaling pathway (Additional files 4 and 5).