And the up-regulated DEGs in “HN vs. NN” were mainly enriched in the pathways in cancer, HIF-1 signaling pathway, AMPK signaling pathway, insulin signaling pathway, and axon guidance pathway; the down-regulated DEGs in “HN vs. NN” were mainly enriched in Foxo signaling pathway, AMPK signaling pathway, insulin signaling pathway, cellular senescence and apoptosis pathway (Fig. 7b). The gene discussed is HIF1A; the disease is cancer.